Elution of Plasticizers from Various Administration Sets after Passing Fat Emulsion through Them
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Accession number;05A0383652
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| Title;Elution of Plasticizers from Various Administration Sets after Passing Fat Emulsion through Them |
| Author;
YONAIYAMA MIO
(Terumo Corp., JPN)
KOYAMA SAWAKO
(Terumo Corp., JPN)
SENSHU KAZUHISA
(Terumo Corp., JPN)
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Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
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Journal Code:Y0888A
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ISSN:1346-342X
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VOL.31;NO.4;PAGE.295-300(2005)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The use of Tris(2-ethylhexyl) trimellitate (TOTM) as an alternative to di(2-ethylhexyl) phthalate (DEHP) as a plasticizer in polyvinyl chloride (PVC) medical devices is steadily increasing. Four types of administration sets are available: general-type sets made of PVC using DEHP (DEHP-PVC) or TOTM (TOTM-PVC) as a plasticizer, pump-type sets made of DEHP-PVC, and those made of polybutadiene (PB). Since the elution of plasticizer from administration sets when specific drugs are passed though them is a matter of concerri, in the present study, we compared the amounts of plasticizer eluted from these 4 types of administration sets after passing fat emulsion through them, for different drip rates. The concentrations of plasticizer eluted were lowest for the TOTM-PVC administration set, followed in ascending order by the general-type DEHP-PVC and pump-type DEHP-PVC sets. Neither DEHP nor TOTM was detected for the PB set. For the general-type administration set, the maximum concentrations of TOTM and DEHP eluted were obtained with a drip rate of 10 mL/hr, which were 0.38.MU.g/mL for TOTM and 10.32.MU.g/mL for DEHP, respectively. At a drip rate of 80 mL/hr, the maximum concentration of DEHP was 0.97.MU.g/mL but TOTM was not detected. These results indicate that TOTM is less easily eluted than DEHP and that TOTM-PVC is an excellent material for administration sets in view of its low elution characteristics, though care needs to be taken with regard to drug adsorption. (author abst.) |
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