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Mechanism of Exercise-Induced ST Depression Based on Hemodynamics During Cardiac Catheterization

Accession number;05A0464560

Title;Mechanism of Exercise-Induced ST Depression Based on Hemodynamics During Cardiac Catheterization

Author; NOIKE HIROFUMI (Toho Univ. School of Medicine., Sakura Hospital, JPN) HITSUMOTO TAKASHI (Toho Univ. School of Medicine., Sakura Hospital, JPN) SUGIYAMA YUKO (Toho Univ. School of Medicine., Sakura Hospital, JPN) SAKURAI TAKESHI (Toho Univ. School of Medicine., Sakura Hospital, JPN) SATO SHIN (Toho Univ. School of Medicine., Sakura Hospital, JPN) IIZUKA TAKUO (Toho Univ. School of Medicine., Sakura Hospital, JPN) TAKAHASHI MAO (Toho Univ. School of Medicine., Sakura Hospital, JPN) SHIMIZU KAZUHIRO (Toho Univ. School of Medicine., Sakura Hospital, JPN) NAKAMURA KEIJIRO (Toho Univ. School of Medicine., Sakura Hospital, JPN)

Journal Title;J Cardiol

Journal Code:Y0264A

ISSN:0914-5087

VOL.45;NO.5;PAGE.193-203(2005)

Figure&Table&Reference;FIG.6, TBL.4, REF.20

Pub. Country;Japan

Language;Japanese

Abstract;Objectives. The cause of exercise-induced ST depression was studied by assessing left ventricular end-diastolic pressure (LVEDP). Methods. This study included 28 patients with normal coronary artery, 24 patients with vasospastic angina pectoris and 28 patients with fixed organic lesion who underwent both treadmill exercise testing and selective coronary arteriography. Exercise-induced ST deviation was considered as maximal ST deviation during the exercise test and maximum LVEDP was considered as the pressure measured 1 min after left ventriculography. Results. The degree of exercise-induced ST depression in aVF showed no significant differences between the three groups. Exercise-induced ST elevation occurred in the intracardiac leads and exercise-induced ST depression occurred in the epicardial leads. These electrocardiographic changes were not contradictory to subendocardial ischemia. In addition, there was a good correlation (r=-0.465, p<0.01) between exercise-induced ST depression and maximum LVEDP elevation. Conclusions. Exercise-induced ST depression was caused by subendocardial ischemia due to increased LVEDP. (author abst.)

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