Report of Japan Diabetes Society Committee on Fulminant Type 1 Diabetes Mellitus Research: Epidemiological and Clinical Analylsis and Proposal of Diagnostic Criteria
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Accession number;05A0522442
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| Title;Report of Japan Diabetes Society Committee on Fulminant Type 1 Diabetes Mellitus Research: Epidemiological and Clinical Analylsis and Proposal of Diagnostic Criteria |
| Author;
HANAFUSA TOSHIAKI
(Osaka Medical. Coll., JPN)
IWAHASHI HIROMI
(Osaka Univ., Grad. Sch.)
UCHIGATA YASUKO
(Diabetes Center, Tokyo Women's Medical Univ., JPN)
KANATSUKA AZUMA
(Chibachuomedikaruse Tonyobyose)
KAWASAKI EIJI
(Nagasakidai Ishi Byoin Seikatsushukanbyoyoboushinryobu)
KOBAYASHI TETSURO
(Yamanashi Univ., JPN)
SHIMADA AKIRA
(Sch. of Med., Keio Univ.)
SHIMIZU IKKI
(Ehimeken'imabaribyoin Naika)
MARUYAMA TARO
(Saitama Social Insurance Hospital, JPN)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.48;NO.Supplement 1;PAGE.A1-A13(2005)
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| Figure&Table&Reference;FIG.6, TBL.4, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: We clarified epidemiological and clinical characteristics and set diagnostic criteria for fulminant type 1 diabetes, a novel subtype of type 1 diabetes mellitus. The Japan Diabetes Society Committee on Fulminant Type 1 Diabetes Mellitus Research was organized for this study. Methods: The committee conducted 2 studies-Study 1 within institutions related to committee members and to reveal the prevalence of fulminant type 1 diabetes in Japan, and Study 2 conducted nationwide to clarify clinical characteristics of fulminant type 1 diabetes. The committee asked members of the Japan Diabetes Society to report patients suspected of fulminant type 1 diabetes mellitus. Characteristics of these patients were compared to classical autoimmune type 1 diabetes mellitus. Following these 2 studies, the committee drew up screening and diagnostic criteria for fulminant type 1 diabetes mellitus. Results: In Study 1, the committee identified 222 patients with acute-onset type 1 diabetes accompanied with ketoacidosis. Of these, 43 (19.4%) were diagnosed with fulminant type 1 diabetes mellitus. In Study 2, the committee diagnosed an additional 118 patients with fulminant type 1 diabetes mellitus outside institutions of committee members. In total, 161 were diagnosed with fulminant type 1 diabetes mellitus, which showed no significant seasonal or regional preference. Compared to 137 autoimmune type 1 diabetes mellitus, fulminant type 1 diabetes mellitus had a significantly shorter duration of hyperglycemic symptoms, a higher prevalence of preceding symptoms, e.g., flu-like symptoms (fever, sore throat etc.) and gastrointestinal symptoms (epigastralgia, nausea, vomiting, etc.), a higher prevalence of disturbance in consciousness, higher plasma glucose, lower HbA1c, more frequent occurrence related to pregnancy, higher prevalence of increased serum pancreatic enzyme, lower C-peptide in serum and urine, lower arterial pH, lower serum Na, and higher serum K.... (author abst.) |
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