Four Cases of Fulminant Type 1 Diabetes Mellitus
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Accession number;05A0522452
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| Title;Four Cases of Fulminant Type 1 Diabetes Mellitus |
| Author;
IMAEDA KENRO
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
OKAYAMA NAOTSUKA
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
KAMIYA YOSHINOBU
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
KATO TAKASHI
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
AKAO MASAYA
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
IMAI SEIJI
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
TAKEUCHI YOSHIYUKI
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
WAKAMI KAZUKO
(Nagoyashidai Byoin Naibumpitsutonyobyonaika)
HAYASHI YOSHINARI
(Toyota Medical Corp., Kariya General Hospital, JPN)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.48;NO.Supplement 1;PAGE.A53-A57(2005)
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| Figure&Table&Reference;TBL.2, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We studied 4 cases of diagnosed or suspected fulminant type 1 diabetes mellitus based on clinical factors, i.e., age, gender, pregnancy, duration between onset of symptoms and diagnosis, HbA1c, autoimmune antibodies, and HLA. Of the 4, 3 were women and a man, and one woman was pregnant. Age ranged from 29 to 69. Cases 3 and 4 had upper bronchitis before hyperglycemic symptom onset. The duration was 2 to 5 days, and the shorter the duration, the lower the HbA1c. None had antibodies against glutamic acid decarboxylase, ICA, or IAA, and only case 1 had ICSA. Three of the 4 had HLA DRB1'*'0405-DQB1'*'0401, as haplotype susceptible to type 1 diabetes in Japanese. Taken together, we suggest that fulminant type 1 diabetes mellitus may be related to a variety of factors, e.g., gender, pregnancy, virus infection and autoimmunity. We also emphasize the importance of the HLA DRB1'*'0405-DQB1'*'0401 haplotype in fulminant type 1 diabetes mellitus onset. (author abst.) |
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