A Study of Multi Drug Resistant Tuberculosis among Patients Attending Teaching Hospital
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Accession number;05A0371126
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| Title;A Study of Multi Drug Resistant Tuberculosis among Patients Attending Teaching Hospital |
| Author;
JANA PULAK KUMAR
(North Bengal Medical Coll., West Bengal, Ind)
SANYAL DEBASISH
(North Bengal Medical Coll., West Bengal, Ind)
DAS IRA
(Dr. B.c. Roy Memorial Hospital For Children, West Bengal, Ind)
BASUTHAKUR SUMITRA
(North Bengal Medical Coll., West Bengal, Ind)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.1;PAGE.27-31(2005)
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| Figure&Table&Reference;FIG.2, REF.13 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: Multi-drug resistant tuberculosis (MDR-TB) is becoming a serious public health problem world-wide. The present study intends to assess the extent of this problem among tuberculosis patients attending hospital. Design: This is cross sectional study of the tuberculosis patients attending to the outpatient department (OPD) of a teaching hospital. Materials and Methods: Suspected TB patients attending hospital were assessed in detail and patients suffering from any other medical and surgical condition unrelated to TB were excluded. Overall, 587 TB were identified and assessed further by detailed history taking, clinical pathological and radiological evaluation. Patients known to be at risk of developing MDR-TB i.e. CAT II treatment failure, relapse or irregular treatment groups were selected for mycobacteria culture and sensitivity from sputum samples using BACTEC460 method. 49 patients (8.35% of total patients) who fulfilled the criteria underwent sputum culture sensitivity test. Results: 26 (53.1%) among the 49 patients were resistant to at least 1 drug. On an average, patients were resistant to more than 1 drug (Mean 1.8.+-.2.4, median 1, range 0-9). Single drug resistance was less frequent as most cases patients were resistant to more than one drug. Single resistance to rifampicin, ethambutol and pyrazinamide was not found in our study. The drug most frequently exhibiting mono-resistance was streptomycin (12.2%). Resistance (either mono or with other drugs) was most frequently seen with INH (40.8%) 16 patients (32.65%) were found to be suffering from MDR-TB. 8 (16.3%) were resistant to 5 or more drugs (MDR-Plus cases). Among the MDR-TB patients, proportion of males (68.75%) was higher compared to non MDR-patients (51.5%). MDR patients were slightly older (30.56.+-.9.53 years) than non-MDR patients (28.91.+-.5.02 years). History of inadequate treatment was present in higher number in MDR-TB patients (62.5%) compared to non-MDR cases (51.5%).... (author abst.) |
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