Circadian Rhythm of Cardiovascular Autonomic Function in Parkinson's Disease and Multiple System Atrophy
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Accession number;05A0371128
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| Title;Circadian Rhythm of Cardiovascular Autonomic Function in Parkinson's Disease and Multiple System Atrophy |
| Author;
HARADA TOSHIHIDE
(Hiroshima International Univ., Hiroshima, Jpn)
ISHIZAKI FUMIKO
(Hiroshima Prefectural Coll. Of Health Sci., Hiroshima, Jpn)
TACHIKI NORIKO
(Hiroshima International Univ., Hiroshima, Jpn)
MATSUMOTO TOMOKO
(Hiroshima International Univ., Hiroshima, Jpn)
HORIE NOBUKO
(Hiroshima International Univ., Hiroshima, Jpn)
NITTA YUMIKO
(Hiroshima Univ., Hiroshima, Jpn)
NITTA KOHSAKU
(Ohtani Rehabilitation Hospital, Hiroshima, Jpn)
INOUE YOSHIO
(Ohtani Rehabilitation Hospital, Hiroshima, Jpn)
OIKAWA KAZUO
(Ohtani Rehabilitation Hospital, Hiroshima, Jpn)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.1;PAGE.37-39(2005)
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| Figure&Table&Reference;REF.29 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: A non-invasive autoregressive approach to spectral analysis of R-R interval variability became providing non-invasive indices of the sympatho-vagal balance modulating the Sino-auricular (SA) node, of the sympathetic vasomotor modulation and of baroreflex control of heart period. Using this approach, we evaluated cardiovascular autonomic function related to the prognosis in patients with Parkinson's disease (PD) and Multiple System Atrophy over 24 hours. Design: A clinical study. Materials and Methods: We investigated the circadian rhythm of heart rate variability (HRV) in normal subjects and patients with Parkinson's disease (PD) and multiple system atrophy (MSA). HRV was evaluated in all subjects using the spectral analysis and low frequency (LF), high frequency (HF) components and the LF/HF ratio (LF/HF) were determined from Holter ECG recordings. Results: The LF, HF powers and LF/HF over 24 hours were reduced in the PD and MSA patients compared with those in the controls. Those in the MSA group tended to be reduced compared with those in the PD group. The HRV parameters at 1-hour intervals in the PD and MSA groups were almost always lower than those in the control group. Those in the MSA group tended to be low compared with those in the PD group. The circadian rhythm of these parameters were also disturbed in the patients. Conclusion: We indicated that PD and MSA patients had impaired circadian rhythm of cardiovascular autonomic function and the impairment in MSA was severe compared with that in PD. Calculating LF, HF powers and LF/HF for 24 hours and analyzing circadian rhythm of these parameters using spectral analysis may be very useful for non-invasively evaluating severity of autonomic dysfunction and carrying out differential diagnosis between PD and MSA. (author abst.) |
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