Hyperhomocysteinemia and Vascular Disease: An Overview
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Accession number;05A0371130
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| Title;Hyperhomocysteinemia and Vascular Disease: An Overview |
| Author;
GOSWAMI BINITA
(Maulana Azad Medical Coll., New Delhi, Ind)
MALLIKA V
(G. B. Pant Hospital, New Delhi, Ind)
RAJAPPA MEDHA
(Maulana Azad Medical Coll., New Delhi, Ind)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.1;PAGE.45-50(2005)
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| Figure&Table&Reference;TBL.1, REF.53 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world. The etiology is multifactorial and includes a number of modifiable and non-modifiable risk factors. However, maximum modification of these risk factors through lifestyle and pharmacological modifications have failed to curtail the deadly impact of this disease on mankind. This has attracted the researchers to identify yet unknown risk factors having an important role in pathogenesis of CAD. The prominent amongst them is homocysteine, whose role in vascular disease is reviewed in this paper. Design: Recent literature review. Methodology: A comprehensive literature search was conducted. The literature was searched from the websites of the National Library of Medicine (http://www.ncbi.nlm.nih.gov/) and PubMed Central, the U.S. National Library of Medicine's digital archive of life sciences journal literature (http://www.pubmedcentral.nih.gov/). The data was accessed from books and journals that published relevant articles in this field. Results: Homocysteine, produced in the metabolism of methionine, was proposed to play a role in the atherothrombotic process, by Wilcken and Wilcken in 1976. Since then it has been the center point of cardiovascular research. Many prospective studies have established the role of homocysteine in eliciting the pathological changes in the vascular endothelium leading to atherogenesis. The main mechanisms involved include-oxidant functions, proaggregatory effect on the coagulation cascade, stimulatory action on the proliferation of vascular and smooth muscle cells by effect on the MAP kinase pathway and number of important effects on gene expression and regulation. Conclusion: Homocysteine has a role in the pathogenesis of CAD and its complications. The deleterious effects of this compound can be annulled by the supplementation of vitamins - Vit B12, folic acid, Vit B6, in the diet.... (author abst.) |
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