Molecular Regulation of Gonadotropin Secretion by Gonadotropin-Releasing Hormone in Salmonid Fishes
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Accession number;05A0507788
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| Title;Molecular Regulation of Gonadotropin Secretion by Gonadotropin-Releasing Hormone in Salmonid Fishes |
| Author;
ANDO HIRONORI
(Kyushu Univ., Fukuoka, Jpn)
URANO AKIHISA
(Hokkaido Univ., Hokkaido, Jpn)
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Journal Title;Zool Sci
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Journal Code:F0012B
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ISSN:0289-0003
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VOL.22;NO.4;PAGE.379-389(2005)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.96 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Gonadotropin-releasing hormone (GnRH) plays a central role in the control of reproductive function in vertebrates. In salmonids, salmon GnRH (sGnRH) secreted by preoptic GnRH neurons regulates gonadal maturation through stimulation of synthesis and release of pituitary gonadotropins (GTHs). In addition, several lines of our evidence indicate that sGnRH is involved in spawning behavior, and serves to integrate the gonadal maturation with the reproductive behavior. A growing number of studies show that the effects of GnRH are mediated by multiple subtypes of GnRH receptors, successive multiple signaling pathways, and finally multiple transcription factors which act cooperatively to stimulate transcription of GTH subunit genes. This complex regulatory system of the action of GnRH may serve as a molecular basis of divergent physiological strategies of reproductive success in various vertebrate species. In this article, recent data on the molecular mechanisms of action of GnRH are reviewed with special reference to the regulation of synthesis and release of GTHs in the pituitary of salmonids to elucidate the multifunctional action of GnRH. (author abst.) |
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