Development of Acetylcysteine Jelly for the Prevention of Radiocontrast-induced Reductions in Renal Function and its Evaluation

Accession number;05A0464597
Title;Development of Acetylcysteine Jelly for the Prevention of Radiocontrast-induced Reductions in Renal Function and its Evaluation
Author; SUDA NORIYUKI (Hokkaido Univ.) SHINZATO RIKA (Hokkaido Inst. of Pharm. Sci., Fac. of Pharm. Sci.) KIYOKAWA MASAMI (Hokkaido Univ.) KANEUCHI MIKI (Hokkaido Inst. of Pharm. Sci., Fac. of Pharm. Sci.) SUGAWARA MITSURU (Hokkaido Univ.) KOORI NAONORI (Hokkaido Inst. of Pharm. Sci., Fac. of Pharm. Sci.) MIYAZAKI KATSUMI (Hokkaido Univ.)
Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
Journal Code:Y0888A
ISSN:1346-342X
VOL.31;NO.5;PAGE.355-359(2005)
Figure&Table&Reference;FIG.6, TBL.1, REF.11
Pub. Country;Japan
Language;Japanese
Abstract;Acetylcysteine is used for the prevention of radiocontrast-induced reductions in renal function. However, as an oral solution, acetylcysteine has an unpleasant taste and smell, which can cause discomfort to patients. To solve this problem, we prepared an oral jelly of acetylcysteine consisting of acetylcysteine, gelatin, flavoring agent and purified water. The unpleasant taste and smell of acetylcysteine were greatly reduced through the use of flavoring agents like apple. We expect our acetylcysteine jelly to be a highly effective preparation for the prevention of radiocontrast-induced reductions in renal function. (author abst.)