Study of Flushing Conditions at Y-site Based on Chemical Compatibility of Injectables

Accession number;05A0464599
Title;Study of Flushing Conditions at Y-site Based on Chemical Compatibility of Injectables
Author; MATSUMOTO SHIGERU (Keisuikai Nadogayabyoin Yakuzaibu) YUMOTO TETSURO (Sagamikoseikai Sogosagamikoseibyoin Yakuzaibu) TANABE TAKUYA (Terumo Corp., JPN) KOYAMA SAWAKO (Terumo Corp., JPN) MIZUKAMI YOSHIAKI (Sagamikoseikai Sogosagamikoseibyoin Yakuzaibu)
Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
Journal Code:Y0888A
ISSN:1346-342X
VOL.31;NO.5;PAGE.367-374(2005)
Figure&Table&Reference;FIG.5, TBL.6, REF.2
Pub. Country;Japan
Language;Japanese
Abstract;When concentrated medical fluids are injected from the Y-site during infusions by such means as the intravenous push or piggyback techniques, drugs occasionally separate out due to their incompatibility. A technique called "flushing" is used to prevent this from happening. This involves the injection of a washing solution, such as physiological saline or glucose solution, from the Y-site before and/or after injection. However, no standards have been established for the use of this technique. To ascertain the most efficient flushing conditions, we studied the relationship among the amount of residual drug in the intravenous tubing, and the volume and rate of flow of the flushing solution (physiological saline) injected from the Y-site with an injectable furosemide (Lasix Injection). The results showed that the volume of physiological saline required to prevent drug incompatibility by flushing out the intravenous tubing was five to six times the inner volume of intravenous tubing, but the flushing rate did not have any effect on flushing. (author abst.)