Genomics Revolution in Contemporary Psychiatric Practices
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Accession number;05A0624398
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| Title;Genomics Revolution in Contemporary Psychiatric Practices |
| Author;
RAZALI SALLEH MOHD
(Universiti Sains Malaysia, Kelantan, Mys)
ZALINA ZAHARI
(Universiti Sains Malaysia, Kelantan, Mys)
TEH LAY KEK
(Universiti Sains Malaysia, Kelantan, Mys)
RUSLI ISMAIL
(Universiti Sains Malaysia, Kelantan, Mys)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.2;PAGE.117-123(2005)
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| Figure&Table&Reference;TBL.2, REF.21 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: To highlight the application of genomic technology in drug development and therapy; and determine the frequency of 7 CYP2D6 alleles (CYP2D6 '*'3, '*'4, '*'6, '*'9, '*'10, '*'14, '*'17) in schizophrenic patients and the relationship with treatment response. This is an early stage of identification of biological predictors of drug efficacy. Materials and Methods: Reviewed of the relevant literatures in the area of pharmacogenetics and pharmacogenomics. Scrutinized the processes of identification of biological predictors of drug efficacy in order to understand the molecular ingredient of antipsychotic drug response and adverse reactions. This is followed by a study that involves 65 schizophrenic patients. Results: Polymorphism of CYP2D6 would contribute to individual variations in response to antipsychotics. Since drug metabolism is determined by the number of functional CYP2D6 gene present, genotyping of patients with CYP2D6 mutations or mutant alleles allows for safer choice of drug and better response to treatment. Thus, genotyping of schizophrenic patients on P 450 enzymes activity would be a predictor outcome in optimizing dosage to prevent side-effect of drug and achieve cost minimization of treatment. In relation to that the present study was conducted. Another pharmacogenetic study is being planned to evaluate the optimum dose of antipsychotic for individual patients. The study revealed that the only mutation detected among the schizophrenic subjects was CYP2D6'*'10. The allele frequency of CYP2D6'*'1 and CYP2D6'*'10 were 78% and 40% respectively.... (author abst.) |
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