Roles of poly(ADP-ribosyl)ation in cell death
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Accession number;05A0630938
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| Title;Roles of poly(ADP-ribosyl)ation in cell death |
| Author;
MARUTA HIDEHARU
(Sci. Univ. of Tokyo, Fac. of Pharm. Sci.)
TANUMA SEIICHI
(Sci. Univ. of Tokyo, Fac. of Pharm. Sci.)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.6;PAGE.484-490(2005)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Poly-(ADP-ribosyl)ation reaction is a post-translational modification that irreversibly modifies chromatin proteins and the like using NAD+ as a substrate. In this reaction, after the ADP-ribose moiety of NAD+ is transferred to the glutamy residue of chromatin proteins, further polymerization takes place to synthesize ADP-ribose polymers and regulate the function of the proteins. Because this modification reaction is different from other modification reactions such as phosphorylation and acetylation and introduces groups with massive electrical charge and molecular weight into the proteins, it changes not only the conformation of the proteins themselves but also interactions between DNA and protein and much of interactions between proteins as well as nucleosomal conformation and, further, high-level chromatin structure. As a result, it plays an important role in DNA repair, cell death, and the like by dynamic changes in the chromatin structure. (Author's abstract). |
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