Involvement of carbohydrate-modification in learning and memory
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Accession number;05A0630939
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| Title;Involvement of carbohydrate-modification in learning and memory |
| Author;
OKA SHOGO
(Kyoto Univ., Graduate School of Pharmaceutical Sciences, JPN)
KAKUDA SHINAKO
(Kyoto Univ., Graduate School of Pharmaceutical Sciences, JPN)
KAWASAKI TOSHISUKE
(Kyoto Univ., Graduate School of Pharmaceutical Sciences, JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.6;PAGE.491-497(2005)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;As a post-genome era is coming up after the completion of human genome decoding, the importance of sugar chains for post-translational modification are receving attention. Many genes related to sugar chains involved in sugar chain synthesis are being cloned as a tool for sugar chain researcdh at present; transgenic and gene-dificient mice are prepared for some of transglycosidases; and functional analyses of sugar chains are in progress. Analyses were recently performed on mice deficient in genes for transglycosidases involved in the biosyntheses of HNK-1 sugar chain and polysialic acid characteristically expressed in a cell adhesion molecule present in the nerve system. It was clarified that these sugar chains were closely involved in the plasticity of nerve and high-level brain functions such as learning memories. (Author's abstract). |
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