Insulin secretion in pancreatic .BETA.-cells: role of protein palmitoylation in glucose-induced insulin secretion
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Accession number;05A0630941
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| Title;Insulin secretion in pancreatic .BETA.-cells: role of protein palmitoylation in glucose-induced insulin secretion |
| Author;
YAMADA SATOKO
(Gunma Univ., Inst. Molecular and Cellular Regulation, JPN)
KOJIMA ITARU
(Gunma Univ., Inst. Molecular and Cellular Regulation, JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.6;PAGE.505-510(2005)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Pancreatic .BETA.-cell is a unique cell that responds to nutrients like glucose and secrets insulin. Because insulin secretion is already selectively inhibited by glucose during the process from before the onset to the early stage of diabetes mellitus, understanding the insulin secretion mechanism of normal .BETA.-cell is important for understanding the disease state of the disease and developing new treatments for the disease. This article discusses the insulin secretion mechanism of .BETA.-cell as it is believed at present. It also describes the possibility that long-chain acyl CoA, a lipid metabolism signal formed by glucose stimulation, is involved in the secretion through palmitoylation of protein. In addition, it outlines the result of our study in which an attempt was made to identify a palmitolation target protein that underwent metabolism-dependent palmitoylation changes and discusses the palmitoylated protein and its function in pancreatic .BETA.-cell. (Author's abstract). |
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