Regulation of tumor malignancy by inhibitors of posttranslational modification of Ras and Rho family proteins
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Accession number;05A0630942
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| Title;Regulation of tumor malignancy by inhibitors of posttranslational modification of Ras and Rho family proteins |
| Author;
IMOTO MASAYA
(Keio Univ., Faculty of Sci. and Technol., JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.6;PAGE.511-518(2005)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Low-molecular-weight G proteins such as those of Ras and Rho families are known to be closely involved in the canceration, malignant degeneration, and metastasis of cells. These proteins commonly undergo post-translational modification, prenylation, such as farnesylation and geranyl-geranylation of cysteine residues in C-A-A-X sequence at the C-terminals, and this post-translational modification is essential for Ras and Rho activation localized in cell membrane. Therefore, for the purpose of developing anticancer drugs wiht a hitherto unknown mechanism, many drugs targeting at enzymes involved in the prenylation of Ras and Rho were developed. These include some still in clinical test at present, which are expected to be new drugs targeting at molecules. On the other hand, these drugs are also important molecular probes for the analysis of control mechanisms of cell responses with proteins of Ras and Rho families. They are also noted from the viewpoint of research on the mechanism of canceration and malignant degeneration. (Author's abstract). |
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