Regulation of cytodifferentiation by retinoylation
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Accession number;05A0630944
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| Title;Regulation of cytodifferentiation by retinoylation |
| Author;
TAKAHASHI NORIKO
(Hoshi Univ., Inst. Med. Chem., JPN)
OBA TOSHIHIRO
(Hoshi Univ., Inst. Med. Chem., JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.6;PAGE.527-536(2005)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Vitamin A acid (retinoic acd, RA) possesses strong ability to induce cell differentiation and is an active ligand used for the treatment of cancer patients, especially patients with acute promyelocytic leukemia. RA actions are thought to manifest via a nuclear receptor. In addition to this mechanism, an action mechanism mediated by protein modification by RA (retinoylation) like retinol expressing visual action was found to exist. This modification covers a wide range, in vitro and in vivo, and appeared on existing proteins. Also, in the differentiation process of HL60 cell strain, RA-caused human myelocytic leukemia cell, most of retinoylated proteins were found to exist in the nucleus and be bound with RA by thiosester. The initial retinoylation of regulating subunit of protein kinase A was found to play an important role in cell differentiation. (Author's abstract). |
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