Immunohistochemical and Lectin-Histochemical Patterns of Renal Non-Neoplastic and Neoplastic Epithelium: Utility of the Patterns in the Differential Diagnosis of Renal Epithelial Tumors
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Accession number;05A0587725
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| Title;Immunohistochemical and Lectin-Histochemical Patterns of Renal Non-Neoplastic and Neoplastic Epithelium: Utility of the Patterns in the Differential Diagnosis of Renal Epithelial Tumors |
| Author;
HAYASHI TOMAYOSHI
(Nagasaki Univ. Hospital, Nagasaki, Jpn)
TSUDA NOBUO
(Nagasaki Prefecture Medical Health Center, Nagasaki, Jpn)
ANAMI MASANOBU
(Nagasaki Univ. Hospital, Nagasaki, Jpn)
CHOWDHURY PARITOSH R.
(Nagasaki Univ. Hospital, Nagasaki, Jpn)
ABE KUNIKO
(Nagasaki Univ. Hospital, Nagasaki, Jpn)
TAMARU NAOE
(Nagasaki Univ. Hospital, Nagasaki, Jpn)
ISEKI MASACHIKA
(Sasebo Kyosai Hospital, Nagasaki, Jpn)
NISHIKIDO MASAHARU
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
KOGA SHIGEHIKO
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
KANETAKE HIROSHI
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
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Journal Title;Acta Med Nagasaki Ensia
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Journal Code:X0952A
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ISSN:0001-6055
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VOL.50;NO.2;PAGE.61-66(2005)
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| Figure&Table&Reference;FIG.10, TBL.2, REF.9 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Renal tumors are considered to be composed of several distinct subtypes with different cell origin. In this study, we tried to find useful immunohistochemical and lectin histochemical patterns for the differential diagnosis and the origin of the tumor relative to the components of the nephron. Typical cases of clear cell carcinoma, granular cell carcinoma, chromophobe cell carcinoma, collecting-duct carcinoma, papillary carcinoma and oncocytoma, as well as sufficient margin of normal renal parenchyma were stained immunohistochemically and lectin-histochemically, using antibodies and lectins reported to show differences in reactivity. Non-neoplastic epithelial cells showed specific reactivity according to the nephron segments. Some of our staining results tended to differ from those reported earlier by other investigators. Neoplastic lesions showed specific immunoreactivities and the staining results were similar to those of the normal nephron segment, suggesting the origin of the respective tumors. Our results suggest that testing the immunoreactivity pattern using a panel of antibodies and lectins is useful for the differential diagnosis of renal neoplastic lesions. (author abst.) |
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