In vitro activity of doripenem against gram-positive and gram-negative bcteria isolates
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Accession number;05A0663307
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| Title;In vitro activity of doripenem against gram-positive and gram-negative bcteria isolates |
| Author;
KUWAHARA KYOKO
(School of Medicine, Juntendo Univ., JPN)
HIRAMATSU KEIICHI
(School of Medicine, Juntendo Univ., JPN)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.53;NO.Supplement 1;PAGE.17-23(2005)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The 90% minimum inhibitory concentrations (MIC90) of the new 1-methylcarbapenem (DRPM) (Shionogi & Co., Ltd., Osaka) against clinical isolates of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, Staphylococcus haemolyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Enterococcus faecium, Moraxella catarrhalis, Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Morganella morganii, Enterobacter cloacae, Serratia marcescens, Pseudomonas aeruginosa were 0.1, 50, 25, 25, 0.2, .LEQ. 0.006, 6.25, > 100, 0.025, 1.56, 0.1, 0.2, 6.25, 0.39, 1.56, 6.25, and 12.5 .MU.g/mL, DRPM showed well-balanced activity against both gram-positive and gram-negative bacteria. The PBPs binding inhibitory pattern of DRPM against MSSA and MRSA was almost the same as that of imipenem. Below 4 .MU.g/mL concentrations, IPM manifested antibiotic activity against S. aureus, stronger than that of DRPM. DRPM exbited higher binding affinity than imipenem to PBPs 3.ALPHA., .BETA. of P. aeruginosa. (author abst.) |
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