In vitro activity of doripenem, a 1.BETA.-methylcarbapenem, against anaerobic bacteria
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Accession number;05A0663308
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| Title;In vitro activity of doripenem, a 1.BETA.-methylcarbapenem, against anaerobic bacteria |
| Author;
TANAKA KAORI
(Gifudai Seimeikagakusogojikkense Kenkiseikinjikkembun'ya)
WATANABE KUNITOMO
(Gifudai Seimeikagakusogojikkense Kenkiseikinjikkembun'ya)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.53;NO.Supplement 1;PAGE.24-31(2005)
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| Figure&Table&Reference;FIG.1, TBL.3, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In vitro activity of doripenem (DRPM), a 1.BETA.-methylcarbapenem, was compared to that of imipenem (IPM), meropenem (MEPM), biapenem (BIPM), and clindamycin (CLDM) against a variety of anaerobic bacteria and a small number of facultative anaerobic bacteria (68 reference strains and 477 clinical isolates). DRPM had a broad spectrum against gram-positive and gram-negative reference strains of anaerobes, inhibiting many anaerobic bacterial strains at 0.78 .MU.g/mL or less. The MIC of DRPM for most reference strains was distributed one- or two- fold higher than that of IPM and MEPM, and one- fold lower than BIPM. For clinical strains, DRPM also showed potent activity. The MIC90 of DRPM for pigmented and non-pigmented Prevotella, Fusobacterium spp., anaerobic gram-positive cocci except for Peptostreptococcus anaerobius, and Clostridium perfringens was 0.39 .MU.g/mL or less. For Bacteroides fragilis and Bacteroides thetaiotaomicron, DRPM showed good activity with a MIC90 of 0.78 .MU.g/mL. Stability of DRPM to 6 .BETA.-lactamases with distinct substrate specificity extracted from 4 strains of B. fragilis and 2 strains of P. bivia was examined. DRPM was hydrolyzed with metallo-.BETA.-lactamase but quite stable with other .BETA.-lactamases. (author abst.) |
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