Evaluation of Blood Coagulation/Fibrinolysis System in Patients with Inflammatory Process
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Accession number;05A0625469
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| Title;Evaluation of Blood Coagulation/Fibrinolysis System in Patients with Inflammatory Process |
| Author;
MARUYAMA IKURO
(Fac. Medicine, Kagoshima Univ., JPN)
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Journal Title;Japanese Journal of Intensive Care Medicine
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Journal Code:Z0581B
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ISSN:0389-1194
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VOL.29;NO.5;PAGE.345-350(2005)
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| Figure&Table&Reference;FIG.5, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The primary role of coagulation reaction is hemostasis and to block blood loss from the circulation. Vessel injury results tissue damage, and induces inflammation. Thus blood coagulation and inflammation have originated form the same pathology. These two reactions are sharing transcription factor, NF-.KAPPA.B and result the linkage between them. Also, these two systems link each other by inflammatory cytokine, IL-1, IL-6 and TNF.ALPHA.. Moreover, CRP, representative inflammatory marker, also plays effect on coagulation, directly or indirectly. Recently identified inflammatory cytokine, HMGB 1, secreted from activated macrophages and dendritic cells, act as an immune adjyuvant and stem cell inducer in topical, however, it acts as a proinflammatory cytokine in the circulation and may result organ failure. The systemic effect of HMGB 1 is blocked by endothelial thromobomodulin. (author abst.) |
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