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Accession number;05A0625470
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| Title;Role of Thrombin and Thrombomodulin in Relation to Close Link between Coagulation and Inflammation |
| Author;
GANDO SATOSHI
(Hokudai Igakukenkyuka Shinshuseigyoigaku Kyukyuigakubun'ya)
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Journal Title;Japanese Journal of Intensive Care Medicine
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Journal Code:Z0581B
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ISSN:0389-1194
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VOL.29;NO.5;PAGE.351-360(2005)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.23 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;This review highlights recent insights into protease-activated receptors (PARs) signaling in the regulation of inflammation and into how the unique structural domains of thrombomodulin effectively control the relationship between coagulation and inflammation. Extrinsic coagulation proteases, their complexes, and thrombin enhance inflammation by activating PARs. Thrombomodulin, activated protein C/endothelial protein C receptor (EPCR), and thrombin activatable fibtinolysis inhibitor (TAFI) play a central role in regulating a inflammation resulted from PARs activation and in cotrolling blood coagulofibrinolytic responses, thus providing a close link between inflammation and coagulation. These data suggest a potential role of extrinsic coagulation pathway and its controling systems in hemostasis and the control of both the coagulation and inflammation. (author abst.) |
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