Trend of New Antipsychotics in Development for Schizophrenia

Accession number;05A0826422
Title;Trend of New Antipsychotics in Development for Schizophrenia
Author; SINGH AMARENDRA N. (Queen's Univ., Ontario, Can)
Journal Title;Int Med J
Journal Code:L4914A
ISSN:1341-2051
VOL.12;NO.3;PAGE.175-180(2005)
Figure&Table&Reference;REF.70
Pub. Country;Japan
Language;English
Abstract;Objective: To evaluate the new offerings of research drugs in schizophrenia and the difficulties encountered. Design: Review of available knowledge of newer drugs in studies for the management of schizophrenia. Materials and Method: Review of available knowledge of ongoing research activities in the area of pharmacotherapy of schizophrenia Results: My own comments on ongoing activities and trends of drugs for the management of schizophrenia. Conclusion: The present armamentarium of antipsychotic drugs has brought new hope and marked revolutionary improvement in the management of schizophrenia. However, the development of new antipsychotics has increased significantly to meet the unmet need of the present armamentarium, like reducing the treatment resistance, enhancing the optimal therapeutic efficacy with a decreased side effect profile, enhancing the control of relapse, quality of life, as well as taking advantage of the huge commercial market. This paper describes some of these drugs, their receptor affinities, therapeutic efficacy and the adverse reaction profiles. (author abst.)