Clinical Significance of Plasma BNP Measurement in Patients with Pychiatric Disease
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Accession number;05A0826423
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| Title;Clinical Significance of Plasma BNP Measurement in Patients with Pychiatric Disease |
| Author;
NAKAE ICHIRO
(Shiga Univ. Medical Sci., Shiga, Jpn)
MATSUO SHINRO
(Shiga Univ. Medical Sci., Shiga, Jpn)
KOH TERUE
(Shiga Univ. Medical Sci., Shiga, Jpn)
MITSUNAMI KENICHI
(Shiga Univ. Medical Sci., Shiga, Jpn)
HORIE MINORU
(Shiga Univ. Medical Sci., Shiga, Jpn)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.3;PAGE.181-184(2005)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: Plasma BNP concentration is a useful marker of cardiac dysfunction which reflects the disease severity. It has been reported that antipsychotic agent may cause fatal cardiac complications along with QT prolongation on electrocardiogram. To investgate potentially progressive cardiac complications by antipsychotic agents, we examined plasma BNP concentrations in schizophrenic patients. Design: A clinical study. Methods: Plasma BNP concentrations in 60 inpatients with schizophrenia were examined. All patients were treated with antipsychotic agents for more than 1 year. The patients with cardiac disease, hypertension, renal dysfunction or diabetes mellitus were excluded. Results: Plasma BNP concentrations were significantly higher in schizophrenic patients than in agematched normal controls (25.0 .+-. 56.8 vs 13.1 .+-. 11.2 pg/ml, p< 0.05). In 5 patients who exhibited higher plasma BNP concentrations, echocardiography failed to detect the abnormality of left ventricular dimension or systolic function. However, plasma BNP concentration correlated positively with the QT interval corrected for heart rate (QTc), suggesting cardiac alteration by antipsychotic agents. Conclusions: Our study suggests that cardiac complications may be potentially advanced in patients treated with antipsychotic agents. The measurement of plasma BNP may be useful for detecting cardiac complications in the early stage. (author abst.) |
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