13-Week Oral Toxicity of Guarana Extract in F344/DuCrj Rats
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Accession number;05A0846431
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| Title;13-Week Oral Toxicity of Guarana Extract in F344/DuCrj Rats |
| Author;
TAMANO SEIKO
(Dims Inst. Medical Sci., Inc.)
KAWABE MAYUMI
(Dims Inst. Medical Sci., Inc.)
HATAHARA YURIKO
(Dims Inst. Medical Sci., Inc.)
SANO MASASHI
(Dims Inst. Medical Sci., Inc.)
HAGIWARA AKIHIRO
(Dims Inst. Medical Sci., Inc.)
FUKUMOTO TAKAYUKI
(San-ei Gen F.f.i., Inc.)
NAKAMURA MIKIO
(San-ei Gen F.f.i., Inc.)
SHIRAI TOMOYUKI
(Nagoya City Univ. Graduate School Of Medical Sci.)
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Journal Title;Japanese Journal of Food Chemistry
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Journal Code:L4470A
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ISSN:1341-2094
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VOL.12;NO.2;PAGE.63-70(2005)
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| Figure&Table&Reference;FIG.2, TBL.6, REF.20 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The potential toxicity of Guarana extract was investigated in groups of 10 F344 rats of each sex given solid diet containing the compound at 0.625, 1.25, 2.5 or 5.0% for 13 weeks. No toxicologically significant treatment-related effects were noted regarding clinical signs, survival rate, body weights, food consumption, food efficiency, urinalyses, hematology, blood biochemistry, ophthalmology and gross pathology. Parameters that showed toxicologically significant alterations with Guarana extract treatment included the following: increased water consumption in the 2.5% or more females; increased salivary gland weights in the 5.0% males and females; increased incidences of an acinar cell hypertrophy in the submandibular and sublingual glands of the 2.5% or more males and females. The present results indicated that the no observed adverse effect level for 13 weeks dietary treatment to be 1.25% (male: 940mg/kg /day, female: 949mg/kg/day) being in accord with 35mg/kg/day of caffeine in both sexes. (author abst.) |
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