Roles of synaptotagmin and its related molecules in membrane trafficking
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Accession number;05A0714517
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| Title;Roles of synaptotagmin and its related molecules in membrane trafficking |
| Author;
FUKUDA MITSUNORI
(Inst. of Physical and Chemical Res.)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.7;PAGE.603-618(2005)
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| Figure&Table&Reference;FIG.6, TBL.2, REF.152 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;"Secretion" in cell physiology means a type of cell membrane traffickings, and the phenomenon od extracellularly discharging follicular contents which are intracellularly transported and fused to cell membrane. Since it essentially requires two membranous bindings to cause the secretion, many of the molecules involving in the control of the secretion have C2 domain, a binding motif of phospholipids constituting cell membranes. The "carboxyl terminal end (C) type tandem C2 protein" which is represented by synaptotagmin mainly exists on the surface of secretory vesicle, and is considered to play an important role for the binding to targeted cell membrane through two C2 domains existing in the C-terminal side. This article describes mainly the function of a synaptotagmin molecule in synaptic vesicle transport by focusing on why two C2 domains are necessary for C type tandem C2 protein, and on what their functional difference are in the control of membrane transport, and outlines the function of C type tandem C2 protein which has been clarified until now. |
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