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Accession number;05A0714518
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| Title;Structure and function of divert glutamate receptor channels |
| Author;
MORI HISASHI
(Toyama Med. and Pharm. Univ.)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.7;PAGE.619-629(2005)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.95 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Glutamate receptor (GluR) channels shouldering rapid excitatory neural transmission in central nervous system are protein molecules which permeate positive ions by binding glutamic acids, and carry out signalling into nerve cells. It has been clarified by gene cloning that mammalian GluR channel gene family includes 18 subunits molecules which are classified into 7 subfamilies. Since each subunit molecule shows divert RNA level and spatiotemporal expression distribution, and divert functions by functional modification and subunit assembly, the diversity of this GluR channel molecule may be the basis of divert cerebral functions. It has been clarified by functional analysis on GluR channel using transgenic mice that each subunit is involved with synaptic plasticity, neuronal circuit formation, and disease state for memory and learning. |
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