Functional analyses of NDRG1, a stress-responsive gene
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Accession number;05A0714519
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| Title;Functional analyses of NDRG1, a stress-responsive gene |
| Author;
OKUDA TOMOHIKO
(National Cardiovascular Center, Res. Inst., JPN)
KOKAME KOICHI
(National Cardiovascular Center, Res. Inst., JPN)
MIYATA TOSHIYUKI
(National Cardiovascular Center, Res. Inst., JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.7;PAGE.630-634(2005)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;NDRG1 is induced to express by various stress stimuli, and is identified as the gene to increase its expression by cancer cells' differentiation induction. It is known to be the responsible gene for Charcot-Marie-Tooth disease type 4D (CMT 4D), an inherited peripheral nerve degenerative disease, but its function is unknown. Ndrg1 knockout mouse is produced, and its phenotype is analyzed. As the result, it becomes clear that NDRG1 is important for maintaining myelin sheath in Schwann cells or glia cells in peripheral nerves. |
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