Structure and mechanism of heme oxygenase
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Accession number;05A0714520
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| Title;Structure and mechanism of heme oxygenase |
| Author;
SAKAMOTO HIROSHI
(Kurume Univ., School of Medicine, JPN)
SUGISHIMA MASAKAZU
(Osaka Univ., Graduate School of Sci., JPN)
HIGASHIMOTO YUICHIRO
(Kurume Univ., School of Medicine, JPN)
FUKUYAMA KEIICHI
(Osaka Univ., Graduate School of Sci., JPN)
NOGUCHI MASATO
(Kurume Univ., School of Medicine, JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.7;PAGE.634-638(2005)
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| Figure&Table&Reference;FIG.3, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Heme oxygenase (HO) decomposes heme, and forms CO, iron, and biliverdine. Though HO has been paid attention to the decomposition of heme, its clinical research is also focused now on behalf of being found proper physiological significance of each HO product such as possibility of CO as a gaseous transmitter, and antioxidant activity of biliverdine. HO reacts as unique as the substrate heme which autocatalytically activates oxygen molecules to gradually decompose HO itself. This article discusses the molecular mechanism of HO reaction on the basis of remarkably advanced research on the structural biology on HO of late. |
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