Characteristics of mucin produced by epithelial cancer cell and its biological significance in cancer tissue
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Accession number;05A0714522
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| Title;Characteristics of mucin produced by epithelial cancer cell and its biological significance in cancer tissue |
| Author;
NAKADA HIROSHI
(Kyoto Sangyo Univ., Faculty of Engineering, JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.7;PAGE.642-646(2005)
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| Figure&Table&Reference;FIG.3, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;It is found during the process to investigate the interaction between mucin produced by epithelial cancer cells and lectin on immunocompetent cells that scavenger receptors (group A type I, and II) on monocytes/macrophages bind to mucin. The research also reveals that cyclooxygenase 2 is induced, and the production of PGE2 is accelerated in monocytes/macrophages. PGE2 has such biological activities as immunosuppression, apoptosis suppression, and acceleration of vascularization, and seems to arrange advantageous environments for growth and progression of cancer cells in the minute environment within carcer tissue by making mucin a starting point. |
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