Growth, differentiation, and regeneration of liver and skin
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Accession number;05A0714525
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| Title;Growth, differentiation, and regeneration of liver and skin |
| Author;
TATENO CHISE
(Hiroshimakensangyokagakugijutsuken)
TATENO CHISE
(Hiroshima Univ., JPN)
YOSHIZATO KATSUTOSHI
(Hiroshimakensangyokagakugijutsuken)
YOSHIZATO KATSUTOSHI
(Hiroshima Univ., JPN)
YOSHIZATO KATSUTOSHI
(Hiroshima Univ., Graduate School of Sci., JPN)
YOSHIZATO KATSUTOSHI
(Hiroshima Univ., JPN)
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Journal Title;Seikagaku
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Journal Code:G0184A
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ISSN:0037-1017
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VOL.77;NO.7;PAGE.655-659(2005)
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| Figure&Table&Reference;FIG.2, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Proliferation potentials of liver and skin are known to be still high in adults. It has been found the site where epidermal stem cells are localized, and established how to culture them, but the location of hepatic stem cells is not elucidated yet. It makes possible both epidermal and hepatic cells proliferate by mixed culture with Swiss 3T3 cells. Though life spans of both epidermal and hepatic cells are greatly different, many common phenomena are observable in development and regeneration processes. Human-derived epidermal cells are grown to a sheet shape, which is actually usedfor treatments such as for thermal burn. Though the effectiveness of transplantation of human hepatic cells for treating the patients with liver diseases has been demonstrated, the shortage of both transplantable livers and hepatic cells becomes a big problem for their clinical applications. If the expression of liver-specific functions and the safety of proliferated human hepatic cells are confirmable in the future, they can be applicable to regeneration medicine for treating patients with hepatic diseases such as hepatic failure and genetic deficit by hepatic cell transpalntation and the materials for hybrid type artificial liver as well. |
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