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Accession number;05A1044270
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| Title;Development of DNA Vaccination in Bovine Using Dectin-2 promoter |
| Author;
BONKOBARA MAKOTO
(Nippon Vet. and Anim. Sci. Univ., Fac of Vet. and Animal Sci.)
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Journal Title;Shokuniku ni kansuru Josei Kenkyu Chosa Seika Hokokusho
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Journal Code:X0296A
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ISSN:
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VOL.23;NO.;PAGE.95-98(2005)
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| Figure&Table&Reference;FIG.4, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Epidermal Langerhans cells (LC) belong to the family of antigen-presenting dendritic cells (DC) responsible for both initiating antigen-specific immunogenic and tolelogenic responses. Moreover, UVB irradiation has been shown to shift LC function from an immunogenic to a tolerogenic antigen-presenting capacity via alterations in the gene expression of LC. Having shown previously that the C-type lectin receptor, dectin-2, is involved in inducing UVB-immunosuppression, we questioned whether UVB irradiation modulates the expression of dectin-2 by LC. We found dectin-2 on LC within mouse epidermis to be upregulated markedly by UVB irradiation but not by treatment with LPS, PMA, IFN.GAMMA. or hapten. Similar results were obserbed in bone marrow-derived DC following UVB irradiation in vitro. UVB-induced upregulation was obserbed in LC at the transcriptional activity of the dectin-2 promoter and the levels of dectin-2 mRNA and protein. These findings lead us to hypothesize that UVB-induced upregulated expression of dectin-2 in LC may be an important mechanism responsible for the capacity of UVB radiation to convert LC into tolerogenic antigen presenting cells, thereby inducing immunosuppression. (author abst.) |
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