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Accession number;05A1044300
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| Title;Effect of Oral Administration of Porcine Cartilage derived Collagens on Elder Rat Articular Cartilage |
| Author;
FUKUNAGA SHIGEHARU
(Hokkaido Univ., Graduate School of Agriculture, JPN)
SEKIGUCHI TAKESHI
(Itoraifusaiensu)
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Journal Title;Shokuniku ni kansuru Josei Kenkyu Chosa Seika Hokokusho
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Journal Code:X0296A
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ISSN:
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VOL.23;NO.;PAGE.258-262(2005)
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| Figure&Table&Reference;FIG.3, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Effect of the porcine cartilage derived collagens includes various proteoglycans as a functional foodstuff on elder rat articular cartilage was studied. The rats that were orally administrated cartilage extracts. The rats aged 80 weeks old were used for experiments. They were divided into two groups one was controls that given basal diet (AIN-93M). The other was experimental group that given cartilage collagens containing diet in which 50% of protein (as nitrogen content base) replaced by that collagens. Each diet and water was given ad libitum. After 12 weeks feeding these diets, rats were killed and cryosection of femur articular cartilage of both groups were made. The sections were stained with hematoxylin and eosin (HE), toluidin blue (TB) and immunohistochemically. The tibia artilucar cartilage was subjected to cell marceration method and observed with SEM. The cartilage of collagen administrated rats showed greater number of chondrocytes in cartilage. The sections of these rats were intensely stained glycosaminoglycans and/or proteoglycans that suggsts abundant proteoglucans were exist Furthermore, conformation of collagen fibers was different between these two groups. Although the mechanisms is unclear, oral administration of cartilage collagen include proteoglycans have some influence on articular cartilage metabolism and may suppress the changes that occur with aging. (author abst.) |
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