In vitro antibacterial activity of moxifloxacin against anaerobic and facultative bacteria
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Accession number;06A0013876
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| Title;In vitro antibacterial activity of moxifloxacin against anaerobic and facultative bacteria |
| Author;
TANAKA KAORI
(Gifu Univ., JPN)
WATANABE KUNITOMO
(Gifu Univ., JPN)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.53;NO.Supplement 3;PAGE.21-26(2005)
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| Figure&Table&Reference;TBL.4, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Moxifloxacin (MFLX), a new synthetic antibacterial, was assessed for in vitro antibacterial activity against anaerobic and facultative bacteria in comparison with cefdinir (CFDN), clavulanic acid/amoxicillin (CVA/AMPC), clarithromycin (CAM), clindamycin (CLDM) and levofloxacin (LVFX). The results obtained are describe below. 1. MFLX showed antibacterial activity against a broad spectrum of reference strains of anaerobic and facultative bacteria, ranging from gram-positive to gram-negative. The MICs of MFLX were .LEQ.2 .MU.g/mL for all of the strains except Clostridium clostridiiforme, C. ramosum, Lactobacillus acidophilus, and Lactobacillus plantarum. 2. The MICs of MFLX for clinical isolates, showed potent antibacterial activity (MIC: .LEQ.0.5 .MU.g/mL) against gram-positive cocci, except F. magna, and against Propionibacterium acnes, and gram-negative Prevotela inter media, Porphyromonas gingivalis, and Fusobacterium nucleatum. The antibacterial activity of MFLX was almost equal to that of CVA/AMPC. The activity of MFLX was also equal to or 4-32 times greater than that of LVFX. (author abst.) |
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