New Stilbenoids from Pholidota yunnanensis and Their Inhibitory Effects on Nitric Oxide Production
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Accession number;06A0025393
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| Title;New Stilbenoids from Pholidota yunnanensis and Their Inhibitory Effects on Nitric Oxide Production |
| Author;
GUO XIAO-YU
(Coll. Of Traditional Chinese Materia Medica, Shenyang Pharmaceutical Univ.)
WANG JUE
(Dep. Of Pharmacognosy, Coll. Of Pharmacy, Nihon Univ.)
WANG NAI-LI
(Coll. Of Traditional Chinese Materia Medica, Shenyang Pharmaceutical Univ.)
WANG NAI-LI
(Shenzhen Res. Center Of Traditional Chinese Medicines And Natural Products, Tsinghua Campus, Univ. Town Of Shenzhen)
KITANAKA SUSUMU
(Dep. Of Pharmacognosy, Coll. Of Pharmacy, Nihon Univ.)
LIU HONG-WEI
(Shenzhen Res. Center Of Traditional Chinese Medicines And Natural Products, Tsinghua Campus, Univ. Town Of Shenzhen)
YAO XIN-SHENG
(Coll. Of Traditional Chinese Materia Medica, Shenyang Pharmaceutical Univ.)
YAO XIN-SHENG
(Shenzhen Res. Center Of Traditional Chinese Medicines And Natural Products, Tsinghua Campus, Univ. Town Of Shenzhen)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.54;NO.1;PAGE.21-25 (J-STAGE)(2006)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.13 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Six new stilbenoids, a (bibenzyldihydrophenanthrene) ether designated phoyunnanin D (1), a bis(dihydrophenanthrene) ether designated phoyunnanin E (2), and four stilbenes designated phoyunbene A-D (3-6), were isolated from the air-dried whole plant of Pholidota yunnanensis ROLFE. The new compounds were identified as 7-[2-(3-hydroxyphenethyl)-4-hydroxy-6-methoxyphenoxy]-4-hydroxy-2-methoxy-9,10-dihydrophenanthrene (1), 1-[(9,10-dihydro-4-hydroxy-2-methoxy-7-phenanthrenyl)oxy]-4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (2), trans-3,3'-dihydroxy-2',4',5-trimethoxystilbene (3), trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene (4), trans-3,3'-dihydroxy-2',5-dimethoxystilbene (5), and trans-3-hydroxy-2',3',5-trimethoxystilbene (6) based on spectroscopic evidence. Furthermore, the inhibitory effects of compounds 1-6 on nitric oxide production in a murine macrophage-like cell line (RAW 264.7) activated by lipopolysaccharide and interferon-.GAMMA. were examined. (Author abst.) |
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