Synthesis, Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin(IV) Complexes Derived from Aminoalcohols
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Accession number;06A0025399
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| Title;Synthesis, Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin(IV) Complexes Derived from Aminoalcohols |
| Author;
GOMEZ ELIZABETH
(Instituto De Quimica-unam, Circuito Exterior, Ciudad Universitaria)
CONTRERAS-ORDONEZ GUADALUPE
(Instituto De Quimica-unam, Circuito Exterior, Ciudad Universitaria)
RAMIREZ-APAN TERESA
(Instituto De Quimica-unam, Circuito Exterior, Ciudad Universitaria)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.54;NO.1;PAGE.54-57 (J-STAGE)(2006)
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| Figure&Table&Reference;TBL.2, REF.27 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The synthesis of pentacoordinated Tin(IV) compounds derived from aminoalcohols is described. The compounds were characterized by IR, '1'H-, '13'C-, and '119'Sn-NMR, the mass spectrometry exhibits molecular ions corresponding to monomeric species. All compounds were evaluated for in vitro cytotoxic activities against five human tumor cell lines, U251 (human glioblastoma), PC-3 (human prostatic adenocarcinoma), K-562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma). The cytotoxic evaluation revealed that all compounds possess higher cytotoxic potency than that of the cisplatin, which was used as reference. Additionally, MT2 cells (human T-lymphocytes) were also evaluated. (Author abst.) |
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