Three New Lignans, Longipedunins A-C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease
|
Accession number;06A0025417
|
| Title;Three New Lignans, Longipedunins A-C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease |
| Author;
SUN QUAN-ZHONG
(Dep. Of Pharmacognosy, School Of Pharmacy, Fudan Univ.)
CHEN DAO-FENG
(Dep. Of Pharmacognosy, School Of Pharmacy, Fudan Univ.)
DING PEI-LAN
(Dep. Of Pharmacognosy, School Of Pharmacy, Fudan Univ.)
MA CHAO-MEI
(Dep. Of Natural Medicines, School Of Pharmaceutical Sciences, Peking Univ.)
KAKUDA HIROKO
(Lab. Of Chemistry, Toyama Medical And Pharmaceutical Univ.)
NAKAMURA NORIO
(Dep. Of Metabolic Engineering, Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.)
HATTORI MASAO
(Dep. Of Metabolic Engineering, Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.)
|
Journal Title;Chem Pharm Bull
|
Journal Code:G0504A
|
ISSN:0009-2363
|
|
VOL.54;NO.1;PAGE.129-132 (J-STAGE)(2006)
|
| Figure&Table&Reference;FIG.3, TBL.3, REF.12 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 .MU.M, respectively. (Author abst.) |
|
|
|
Related Articles;
|
|
|
