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Accession number;06A0028770
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| Title;Electrochemical Determination of Minoxidil in Different Pharmaceutical Formulations by Flow Injection Analysis |
| Author;
PFAFFEN VALERIA
(Universidad Nacional De Cordoba, Cordoba, Arg)
ORTIZ PATRICIA I.
(Universidad Nacional De Cordoba, Cordoba, Arg)
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Journal Title;Anal Sci
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Journal Code:G0673B
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ISSN:0910-6340
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VOL.22;NO.1;PAGE.91-94(2006)
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| Figure&Table&Reference;FIG.6, TBL.1, REF.26 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The electrochemical behavior and amperometric-FIA quantification of minoxidil at a glassy carbon electrode is described. The procedure is based on electrochemical oxidation at 0.800 V (vs. Ag/AgCl/NaCl(3 M) in a phosphate buffer solution. Minoxidil was determined over the range 1 * 10'-7'-1 * 10'-4' M. Different analytical parameters and electrode stability were analyzed to obtain the best electrode performance. The optimal conditions were: working potentials, 0.800 V; flow rate, 0.74 mL min'-1'; and solution pH 7.0. This system allowed a sampling rate of 120 samples per hour without any pretreatment. The proposed method was used for minoxidil quantification in pharmaceutical preparations with satisfactory results. The accuracy of FIA-amperometric method was established by a comparison with the conventional UV determination technique using a paired t-test indicating the absence of systematic errors. (author abst.) |
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