Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection
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Accession number;06A0028790
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| Title;Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection |
| Author;
ZHANG DEYI
(Northwest Normal Univ., Lanzhou, Chn)
MA YONGJUN
(Northwest Normal Univ., Lanzhou, Chn)
ZHOU MIN
(Northwest Normal Univ., Lanzhou, Chn)
LI LI
(Northwest Normal Univ., Lanzhou, Chn)
CHEN HUI
(Gansu Key Lab. Polymer Materials, Lanzhou, Chn)
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Journal Title;Anal Sci
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Journal Code:G0673B
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ISSN:0910-6340
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VOL.22;NO.1;PAGE.183-186(2006)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.18 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Based on the chemiluminescence (CL) emission generated from the oxidation of ceftriaxone sodium alkali hydrolysate by potassium permanganate in polyphosphoric acid (PPA), a novel determination method for ceftriaxone sodium was developed by using a flow-injection technique. The calibration curve appears to be linear in the range between 0.05 and 100 .MU.g mL'-1' with a detection limit (3.SIGMA.) of 25 ng mL'-1', and a relative standard deviation (RSD) of 0.6% for eleven replicate determinations of 5.0 .MU.g mL'-1' ceftriaxone sodium. The proposed method has been successfully utilized for the determination of ceftriaxone sodium in pharmaceutical formulations, while the chemiluminescence reaction mechanisms were investigated. (author abst.) |
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