New Perspectives in the Treatment of Bipolar Affective Disorder

Accession number;06A0032848
Title;New Perspectives in the Treatment of Bipolar Affective Disorder
Author; JAINER A.K. (Caludon Center, Coventry, Gbr) KING METIEDETT (Warwick Medical School, Coventry, Gbr) SRIDHARAN SANJANA (Caludon Center, Coventry, Gbr) RAAYASA SRIKANTH (Caludon Center, Coventry, Gbr)
Journal Title;Int Med J
Journal Code:L4914A
ISSN:1341-2051
VOL.12;NO.4;PAGE.247-250(2005)
Figure&Table&Reference;FIG.1, REF.28
Pub. Country;Japan
Language;English
Abstract;Objective: To update evidence from studies on advances in pharmacotherapy of bipolar disorder. Methods: A comprehensive literature search was conducted. The literature was searched with Medline, EMBASE, Cochran, and Psych LIT data base. Literature search of papers published up to January 2005 was conducted. Additional articles were retrieved by scrutinizing the bibliographies of review papers. The relevant studies were identified and were evaluated in order to update the evidence by three authors. This does not extend to bipolar depression as evidence is at the moment sparse and limited to only some agents. Results: Recently atypical antipsychotic drugs such as olanzapine, risperidone, quetiapine, aripiprazole and ziprasodone have been systematically tested in the treatment of acute mania. Olanzapine also has been assessed for the maintenance treatment of bipolar disorder. Data from double-blind controlled trials have demonstrated that atypical antipsychotics are as effective as traditional mood stabilizers such as lithium and sodium valproate. Olanzapine has been examined and demonstrated its efficacy in long-term treatment in double-blind controlled trials. Conclusion: Studies in bipolar patients with acute mania indicate that atypical antipsychotics are effective and well-tolerated when used alone or in combination with conventional mood stabilizers, producing a rapid and beneficial reduction in the symptoms of acute mania. (author abst.)
Related Articles;
Loading...