Possible Predictors of Response to Paroxetine for Depression
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Accession number;06A0032852
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| Title;Possible Predictors of Response to Paroxetine for Depression |
| Author;
MORISHITA SHIGERU
(Kyoto Jujo Hospital, Kyoto, Jpn)
ARITA SEIZABURO
(Kansai Medical School, Osaka, Jpn)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.4;PAGE.271-273(2005)
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| Figure&Table&Reference;TBL.2, REF.14 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: An investigation of the characteristics of patients being treated with antidepressants would seem to be useful in determining which patients would be most likely benefit from antidepressants medication. The purpose of this clinical practice was to examine the possible predictors of response to paroxetine for depression. Design: A retrospective cohort analysis was carried out among depression patients treated in the Department of Psychiatry, Kawasaki Medical School Hospital, Kurashiki, Japan, in 2001. Materials and Methods: Seventy-nine patients were identified who were receiving paroxetine to treat depression. A Weibull regression model and the chi-square test were used to test the significance of these clinical factors as predictors of responder resulting from paroxetine treatment. Results: A variety of clinical factors including age, gender, type of depression, frequency of episodes, family history and daily dose of paroxetine were examined as possible predictors of the response to paroxetine. A Weibull regression analysis showed frequency of episodes to be the independent predictive factor of response in paroxetine treatment. The response of a first episode was significantly greater than that of a recurrent episode (.CHI.'2'=9.942, df=1, P=0.0028). Conclusion: The frequency of episodes may be considered as a predictor of the response to paroxetine treatment for depression. This result should be examined in future prospective study. (author abst.) |
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