Effects of Long-Term Statin on Carotid Intima-Media Thickness in Patients with Hypercholesterolemia
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Accession number;06A0032855
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| Title;Effects of Long-Term Statin on Carotid Intima-Media Thickness in Patients with Hypercholesterolemia |
| Author;
KOTANI KAZUHIKO
(Tottori Univ., Tottori, Jpn)
KOTANI KAZUHIKO
(Tottori Univ., Yonago, Jpn)
KURASAWA GOTARO
(Nishi-agatsuma Welfare Hospital, Gunma, Jpn)
SAIGA KYOKO
(Tottori Univ., Tottori, Jpn)
SAIGA KYOKO
(Tottori Univ., Yonago, Jpn)
SAKANE NAOKI
(National Hospital Organization Kyoto Medical Center, Kyoto, Jpn)
TAMURA YOSHISATO
(Nawa Public Clinic, Tottori, Jpn)
HOSODA TAKENOBU
(Tottori Univ., Yonago, Jpn)
KUROZAWA YOUICHI
(Tottori Univ., Yonago, Jpn)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.4;PAGE.287-290(2005)
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| Figure&Table&Reference;FIG.2, REF.10 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: This study assessed long-term effects of simvastatin over a 10-year period on carotid intima-media thickness (CIMT), which is a surrogate marker for atherosclerosis progression, in Japanese adults with asymptomatic hypercholesterolemia. Design: Clinical case-control study. Methods and subjects: 122 patients with mild to moderate asymptomatic hypercholesterolemia, aged 45 to 90, were divided into two groups according to their treatment status: the INITIAL-group consisted of untreated patients with at least 2 years of hypercholesterolemia and the LONG-group consisted of patients using simvastatin 5 mg daily for at least 10 years. Clinical characteristics, including age and smoking, were collected. CIMT was examined with B-mode ultrasound measurements. Results: The parameters such as mean age, sex ratio, smoking status, BMI, blood pressure, lipid panels, glucose, insulin and CIMT values did not differ between the INITIAL- and LONG-groups. Among patients with 240-280 mg/dl of total cholesterol, the LONG-group had significantly lower mean CIMT values than the INITIAL-group (0.97 mm (SD 0.19) in the INITIAL-group vs. 0.86 mm (0.14) in the LONG-group, p<0.05). Conclusion: This study suggested that long-term simvastatin therapy over 10 years, even if the treatment was a conventional dose for Japanese patients, might have a favorable effect on increased CIMT in subjects with hypercholesterolemia, especially of certain group with relatively higher TC levels as 240-280 mg/dl. (author abst.) |
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