Relationship between Characteristics of Genetic Study and Polyneuropathy in Aged Patients
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Accession number;06A0032856
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| Title;Relationship between Characteristics of Genetic Study and Polyneuropathy in Aged Patients |
| Author;
HARADA TOSHIHIDE
(Hiroshima International Univ., Hiroshima, Jpn)
ISHIZAKI FUMIKO
(Prefectural Hiroshima Univ., Hiroshima, Jpn)
YAMAMURA YASUHIRO
(Baba Hospital, Hiroshima, Jpn)
NAKAMURA SHIGENOBU
(Otowa Hospital, Kyoto, Jpn)
DATE YUKARI
(Miyazaki Medical Coll., Miyazaki, Jpn)
NAKAZATO MASAMITSU
(Miyazaki Medical Coll., Miyazaki, Jpn)
NITTA YUMIKO
(Hiroshima Univ., Hiroshima, Jpn)
NITTA KOHSAKU
(Senogawa Hospital, Hiroshima, Jpn)
TSUKUE ICHIRO
(Senogawa Hospital, Hiroshima, Jpn)
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Journal Title;Int Med J
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Journal Code:L4914A
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ISSN:1341-2051
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VOL.12;NO.4;PAGE.291-293(2005)
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| Figure&Table&Reference;REF.8 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: We reported a 62-year-old man with late-onset familial amyloid polyneuropathy type I (FAP I) from Ehime Prefecture. Design: A clinical study. Materials and Methods: We encountered the 62-year-old man with late-onset FAP I (transthyretin Met 30-associated familial amyloid polyneuropathy: FAP TTR Met 30). He demonstrated paraesthesias in the legs and autonomic nervous symptoms at the age of 52. These symptoms gradually developed. Analysis of the transthyretin gene from his leucocytes demonstrated Met 30 transthyretin mutation. Results: Therefore, he was diagnosed with the late-onset FAP I (FAP TTR Met 30). In some families, asymptomatic carriers with the mutant transthyretin gene have been diagnosed. The liver transplantation (brain death or living-related) will be performed, if possible. Conclusion: There was no family history related to any endemic Japanese foci such as Nagano foci and Kumamoto foci. (author abst.) |
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