Characterization and Evaluation of Silk Protein Hydrogels for Drug Delivery

Accession number;06A0107324
Title;Characterization and Evaluation of Silk Protein Hydrogels for Drug Delivery
Author; FANG JIA-YOU (Pharmaceutics Lab., Graduate Inst. Of Natural Products, Chang Gung Univ.) CHEN JYH-PING (Graduate Inst. Of Biochemical And Biomedical Engineering, Chang Gung Univ.) LEU YANN-LII (Natural Products Lab., Graduate Inst. Of Natural Products, Chang Gung Univ.) WANG HSIN-YUAN (Pharmaceutics Lab., Graduate Inst. Of Natural Products, Chang Gung Univ.)
Journal Title;Chem Pharm Bull
Journal Code:G0504A
ISSN:0009-2363
VOL.54;NO.2;PAGE.156-162 (J-STAGE)(2006)
Figure&Table&Reference;FIG.6, TBL.2, REF.25
Pub. Country;Japan
Language;English
Abstract;The objective of this study was to characterize and evaluate the physicochemical properties and drug release profiles of hydrogels composed of silk protein (SP) polymers. SPs with a low MW (SPL, ca. 18 kDa) and a high MW (SPH, ca. 76 kDa) were used for preparing hydrogels. Both the random coil form and .BETA.-sheet conformation simultaneously existed in the hydrogels according to Fourier-transformed IR determination. Morphologically, the hydrogels showed a sponge-like cross-linked structure produced by physical entanglement as well as chemical hydrogen and covalent bindings. The in vitro buprenorphine delivery from SPH hydrogels showed a slow-release effect, and a zero-order rate was obtained for all preparations. Drug release could be controlled by varying the SPH concentrations or incorporation of SPL into the systems. SP hydrogels showed a stronger barrier property for hydrophilic solutes than for hydrophobic solutes. The incorporation of SPH into Pluronic F-127 (PF-127) hydrogels changed the gel structure from amorphous micelles to a regularly interconnected texture with pores. Furthermore, SPH as an adjuvant polymer in PF-127 and chitosan hydrogels lowered and controlled the amount of drug released from those systems. (Author abst.)
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