Expeditious Syntheses of Conjugated Allenyl Esters and Oxazoles through a Cascade Reaction of .ALPHA.-Alkynyl Malonates under Alkaline Conditions
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Accession number;06A0107330
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| Title;Expeditious Syntheses of Conjugated Allenyl Esters and Oxazoles through a Cascade Reaction of .ALPHA.-Alkynyl Malonates under Alkaline Conditions |
| Author;
SANO SHIGEKI
(Graduate School Of Pharmaceutical Sciences, The Univ. Of Tokushima)
SHIMIZU HISASHI
(Graduate School Of Pharmaceutical Sciences, The Univ. Of Tokushima)
KIM KWEON
(Graduate School Of Pharmaceutical Sciences, The Univ. Of Tokushima)
LEE WOO SONG
(Graduate School Of Pharmaceutical Sciences, The Univ. Of Tokushima)
SHIRO MOTOO
(Rigaku Corp.)
NAGAO YOSHIMITSU
(Graduate School Of Pharmaceutical Sciences, The Univ. Of Tokushima)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.54;NO.2;PAGE.196-203 (J-STAGE)(2006)
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| Figure&Table&Reference;FIG.2, TBL.4, REF.50 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Diethyl .ALPHA.-alkynyl-.ALPHA.-methoxymalonates (2a-e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a-e) in high yields, and similar alkaline treatment of diethyl .ALPHA.-alkynyl-.ALPHA.-acetylaminomalonates (5a, b, d, e) furnished unexpectedly the oxazoles (7a, b, d, e) having three substituent groups in excellent yields. (Author abst.) |
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