Sensitive in vivo Assay System for Human Stem Cells Using NOD/SCID/.GAMMA.c'null' mice
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Accession number;06A0107590
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| Title;Sensitive in vivo Assay System for Human Stem Cells Using NOD/SCID/.GAMMA.c'null' mice |
| Author;
HIRAMATSU HIDEFUMI
(Kyoto Univ., Kyoto, Jpn)
FUJINO HISANORI
(Kyoto Univ., Kyoto, Jpn)
HEIKE TOSHIO
(Kyoto Univ., Kyoto, Jpn)
ITO MAMORU
(Central Inst. For Experimental Animals, Kanagawa, Jpn)
NAKAHATA TATSUTOSHI
(Kyoto Univ., Kyoto, Jpn)
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Journal Title;Acta Med Nagasaki Ensia
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Journal Code:X0952A
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ISSN:0001-6055
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VOL.50;NO.Supplement 1;PAGE.39-43(2005)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.13 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Recent advances in stem cell research present us promising possibilities for regenerative medicine. However, investigation on human stem cells is behind from those of murine mostly due to the lack of appropriate analyzing systems. Our NOD/SCID/.GAMMA.c'null' (NOG) mice model realized complete reconstitution of lympho-hematopoietic system as well as liver regeneration by human hematopoietic stem cell transplantation. This model will provide a versatile tool to investigate not only human hematopoietic system but also other human stem cell systems along with stem cell plasticity. (author abst.) |
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