Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer
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Accession number;06A0107598
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| Title;Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer |
| Author;
NAKASHIMA MASAHIRO
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
TAKAMURA NOBORU
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
NAMBA HIROYUKI
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
SAENKO VLADIMIR
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
HAYASHI TOMAYOSHI
(Nagasaki Univ. Hospital, Nagasaki, Jpn)
SEKINE ICHIRO
(Nagasaki Univ. Graduate School Of Biomedical Sci., Nagasaki, Jpn)
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Journal Title;Acta Med Nagasaki Ensia
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Journal Code:X0952A
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ISSN:0001-6055
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VOL.50;NO.Supplement 1;PAGE.87-89(2005)
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| Figure&Table&Reference;TBL.2, REF.5 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Radiation etiology is well known in thyroid carcinogenesis. Ret rearrangement is the commonest oncogenic alterations in Chernobyl-related papillary thyroid cancer (PTC). To evaluate whether there is a radiation signature, we analyzed Ret rearrangement in radiation-associated thyroid cancers with fluorescence in situ hybridization (FISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). The FISH analysis demonstrated segmental jumping translocation (SJT) of Ret gene in radiation-associated thyroid cancers but not in sporadic well differentiated PTC. Furthermore, Ret SJT was commonly observed in anaplastic thyroid cancer (ATC) including both radiation-associated and sporadic cancers. In PTC, Ret SJT was restricted to radiation-associated or high-grade cases. Because Ret SJT was not observed in sporadic, well differentiated and low-grade cases of PTC, Ret SJT might be a molecular marker for radiation-induced and/or aggressive cases of PTC. SJTs are unbalanced translocations involving a donor chromosome arm or chromosome segment that has fused to multiple recipient chromosome, and mainly reported in treatment-related leukemias, while very rare in solid cancers. We found SJT in radiation-induced and high-grade thyroid cancers, suggesting chromosomal instability. This is the first report showing SJT in thyroid cancer, and probably the third report showing SJT in solid cancer in vivo. (author abst.) |
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