Correlation of the Cognitive Function and the Duration of the Illness with the Regional Cerebral Blood Flow in the Patients with Parkinson's Disease: Objective Evaluation Using Stereotactic Extraction Estimation Analysis in '123'I-IMP SPECT
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Accession number;06A0103394
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| Title;Correlation of the Cognitive Function and the Duration of the Illness with the Regional Cerebral Blood Flow in the Patients with Parkinson's Disease: Objective Evaluation Using Stereotactic Extraction Estimation Analysis in '123'I-IMP SPECT |
| Author;
SAKAI TOSHIYUKI
(Saiseikai Matsusaka General Hospital, JPN)
KUZUHARA SHIGEKI
(Fac. Medicine, Mie Univ., JPN)
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Journal Title;Brain Nerve
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Journal Code:Z0685A
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ISSN:0006-8969
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VOL.58;NO.1;PAGE.29-37(2006)
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| Figure&Table&Reference;FIG.3, TBL.4, REF.27 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objective: To investigate the correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow (rCBF) in patients with Parkinson's disease (PD), by means of an objective diagnostic index of brain imaging, stereotactic extraction estimation (SEE) of '123'I-IMP SPECT. Patients and methods: We examined '123'I-IMP SPECT in 24 patients with PD (age=71.79.+-.5.18 years; the Mini-Mental State Examination: MMSE score=21.46.+-.7.62 points; the duration of the illness=6.63.+-.3.91 years; Yahr scale=3.29.+-.0.74). A contrast database was created by averaging extracted database sets of the contrast group (numbers=14 cases; age=74.64.+-.5.99 years, the MMSE score.GEQ.29 points). We applied SEE for Z-score images of three-dimensional stereotactic surface projection analysis (3D-SSP) for '123'I-IMP SPECT, and calculated Z'*' extent ratio by taking advantage of severity of Z-score (the mean value) with extent ratio (%) in the frontal, occipital, temporal, parietal and posterior cingulate cortices, and precuneus, respectively. We investigated the correlation coefficient between the MMSE score and Z'*' extent ratio, and between the duration of the illness and Z'*' extent ratio in the six regions. In addition, we compared Z'*' extent ratio in the six regions between the non-demented group (numbers=12 patients; MMSE.GEQ.24 points) and the demented group (numbers=12 patients; E score.LEQ.23 points). Results: There were negative correlations between the MMSE score and Z'*' extent ratio in the temporal (p<0.05) and posterior cingulate cortices (p<0.05), and positive correlations between the duration of the illness and Z'*' extent ratio in the frontal (p<0.01), temporal (p<0.01), parietal (p<0.05) and posterior cingulate cortices (p<0.01). Z'*' extent ratio was significantly high only in the posterior cingulate cortex (p<0.05) in the demented group.... (author abst.) |
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