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Accession number;06A0103396
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| Title;Expression of Cyclooxygenase (COX)-2 in Astrocytic Tumors and Anti-tumor Effects of Selective COX-2 inhibitors |
| Author;
MURAKAMI HIROMI
(Hokuto Hokutobyoin Shuyoiken)
SAWA HIROKI
(Hokuto Hokutobyoin Shuyoiken)
SAWA HIROKI
(Hokuto Hokutobyoin Noshinkeigeka)
KAMADA HAJIME
(Hokuto Hokutobyoin Noshinkeigeka)
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Journal Title;Brain Nerve
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Journal Code:Z0685A
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ISSN:0006-8969
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VOL.58;NO.1;PAGE.43-49(2006)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Cyclooxygenase (COX)-2 of astrocytic tumors was studied by immunohistochemistry. COX-2 was expressed in 8 of 12 (75%) glioblastoma multiforme, 1 of 7 (14%) anaplastic astrocytoma, but none in astrocytoma. COX-2 was detected by an immnoblotting in 2 of 9 human glioblastoma cell lines (KNS42 and U138). In glioblastoma cell lines, NS398 and Etodolac inhibited cell proliferation and induced apoptosis. The result showed that COX-2 expression may be related with histological grades and COX-2 inhibitors will be one of promising therapeutic tools in human astrocytic tumors. (author abst.) |
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