Effects of a dietary fiber on plasma and liver lipids in mice fed a high-fat diet
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Accession number;06A0105066
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| Title;Effects of a dietary fiber on plasma and liver lipids in mice fed a high-fat diet |
| Author;
ISHIKAWA YUKO
(Kagawa Nutrition Univ., Saitama, Jpn)
OHGUSHI SACHIKO
(Kagawa Nutrition Univ., Saitama, Jpn)
KUDO HIDEKI
(Kagawa Nutrition Univ., Saitama, Jpn)
SUZUKI SATOE
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
SASSA SHUJI
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
SAKAMOTO SHINOBU
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.1;PAGE.41-47(2006)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Obesity is the most significant risk factor for the development of fatty liver and coronary heart disease, but a high-fiber weight reduction diet is known to induce bone loss. In the present study, we investigated the effects of a high-fiber supplement on body growth, plasma levels of lipids, liver and bone in young male mice fed a high-fat diet. Although the high-fat diet increased body growth, plasma levels of lipids and lipid deposits in liver cytoplasm, the high-fiber supplement markedly reduced the extent of the increases. Bone mineral density was unchanged after four weeks on the high-fiber supplement, which enhanced the activity of plasma alkaline phosphatase, i.e. it was speculated to occur in a high-turnover phase of bone metabolism. Dieting can prevent the progression of coronary heart disease resulted in obesity, hypercholesterolemia and hypertension. However, excessive dieting is suspected to induce bone loss resulting in fractures. (author abst.) |
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