The Effect of Interleukin-1 Receptor Antagonist on Arteries and Cholesterol Metabolism
|
Accession number;06A0174931
|
| Title;The Effect of Interleukin-1 Receptor Antagonist on Arteries and Cholesterol Metabolism |
| Author;
ISODA KIKUO
(Internal Medicine I, National Defense Medical Coll., Tokorozawa, Jpn)
OHSUZU FUMITAKA
(Internal Medicine I, National Defense Medical Coll., Tokorozawa, Jpn)
|
Journal Title;J Atheroscler Thromb
|
Journal Code:L2187A
|
ISSN:1340-3478
|
|
VOL.13;NO.1;PAGE.21-30 (J-STAGE)(2006)
|
| Figure&Table&Reference;FIG.4, REF.76 |
| Pub. Country;Japan |
| Language;English |
| Abstract;This review summarizes both the structure and function of IL-1 receptor antagonist (IL-1Ra), and relates our new findings, particularly those obtained in IL-1Ra-deficient mice (IL-1Ra'-/-'), to the role of IL-1Ra in arterial diseases and cholesterol metabolism. IL-1Ra'-/-' mice show an increase in neointima-formation after arterial injury. Heterozygosity in the IL-1Ra gene against the apolipoprotein E-deficient background revealed a role for IL-1 in promoting atherogenic cell signaling and that the larger lesions of IL-1Ra'-/-' mice are enriched in macrophages and depleted of smooth muscle cells. Furthermore, IL-1Ra'-/-' mice developed severe fatty livers and hypercholesteroremia following 20 weeks on a atherogenic diet compared to WT mice. Taken together, these results suggest that IL-1Ra plays important roles in restenosis after angioplasty, the development of atherosclerosis, and the metabolism of cholesterol in vivo. (Author abst.) |
|
|
|
Related Articles;
|
|
|
